Background
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq].
Product Information
Source: E coli; insect cells; or mammalian cells: 293, CHO
| Purity: Greater than 95.0% as determined by RP-HPLC or SDS-PAGE analysis.
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: ACVRL1
| Gene Symbol: ACVRLK1, ALK1, ALK1, HHT, HHT2, ORW2, SKR3, TSRI
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Gene Name Synonyms: ACVRLK1, ALK1, ALK1, HHT, HHT2, ORW2, SKR3, TSRI
| NCBI Acc#: NM_000020
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Chromosomal Location: 12q11-q14
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Availability
Custom Expression: 4 to 10 weeks
