Background
The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
|
Purification Method: FPLC
| |
Gene/Protein Information
Gene Name: ADRBK1
| Gene Symbol: BARK1, BETAARK1, GRK2
|
Gene Name Synonyms: BARK1, BETAARK1, GRK2
| NCBI Acc#: NM_001619
|
Chromosomal Location: 11q13
| |
