Background
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: BUB1B
| Gene Symbol: BUB1beta, BUBR1, Bub1A, MAD3L, SSK1, hBUBR1
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Gene Name Synonyms: BUB1beta, BUBR1, Bub1A, MAD3L, SSK1, hBUBR1
| NCBI Acc#: NM_001211
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Chromosomal Location: 15q15
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