Background
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Product Information
Source: Purified from human 293 cells expressing 1-297 amino acids of CDC2 (kinase domain: 4-287). Contact us for custom expression of this protein in 293 or Sf9 cells
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: cell division cycle 2 isoform 2
| Gene Symbol: CDK1
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Gene Name Synonyms: CDC2; CDC28A; DKFZp686L20222; MGC111195;
| NCBI Acc#: P06493
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Sequence
MEDYTKIEKI...NDLDNQIKKM
Storage Condition
Store at 4°C if entire vial will be used within 2 weeks. Store frozen at -20°C or -80°C for longer periods of time.
