EPH receptor A8, EPHA8
eph- and elk-related tyrosine kinase, ephrin type-A receptor 8 precursor, hydroxyaryl-protein kinase, protein-tyrosine kinase, tyrosine-protein kinase receptor eek, tyrosylprotein kinase

  Background  
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq].

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  Gene/Protein Information