Human ERK2/MAPK1, recombinantly expressed in E. coli. Unactive form not phosphorylated by MEK1. Molecular weight based on amino acid sequence 44.6 kDa. Purity > 95% (SDS PAGE). Specific activity < 100 Units/mg. No protease activity detectable.
Alternate Names: p42, p42 MAPK, p42MAPK, mitogen-activated protein kinase 1, MAP kinase 1, MAPK1, extracellular signal-regulated kinase 2, p42 ERK2, p42ERK2
Size: 10 µg
Ordering information: shipped on dry ice
Product specific literature references:
Gonzalez FA, Raden DL, Davis RJ (1991) "Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases" J. Biol. Chem. 266(33):22159-63
Haycock JW, Ahn NG, Cobb MH, Krebs EG (1992) "ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ" Proc. Natl. Acad. Sci. U S A. 89(6):2365-9
Volente C, Angelastro JM, Greene LA (1993) "Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors" J. Biol. Chem. 268(28):21410-5
Veeranna, Amin ND, Ahn NG, Jaffe H, Winters CA, Grant P, Pant HC (1998) "Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M" J. Neurosci. 18(11):4008-21
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