Background
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: EIF2AK3
| Gene Symbol: DKFZp781H1925, PEK, PERK, WRS
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Gene Name Synonyms: DKFZp781H1925, PEK, PERK, WRS
| NCBI Acc#: NM_004836
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Chromosomal Location: 2p12
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