Background
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: FGR
| Gene Symbol: FLJ43153, MGC75096, SRC2, cfgr, csrc2, p55cfgr, p58cfgr
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Gene Name Synonyms: FLJ43153, MGC75096, SRC2, cfgr, csrc2, p55cfgr, p58cfgr
| NCBI Acc#: NM_001042729
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Chromosomal Location: 1p36.2-p36.1
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