Background
This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: GUCY2D
| Gene Symbol: CORD5, CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, RETGC1, ROSGC1, retGC
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Gene Name Synonyms: CORD5, CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, RETGC1, ROSGC1, retGC
| NCBI Acc#: NM_000180
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Chromosomal Location: 17p13.1
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