PKC alpha: Human, recombinant Protein kinase C alpha, active, C-terminal His Fusion protein (3500 units)
Protein kinase C (PKC) is a family of serine-threonine kinases, which are classified into three major groups: classical (α, β and γ), novel (δ, ε, η, and θ) and atypical (μ, ξ and ι). Protein kinase C alpha (PKC alpha) is an ubiquitously expressed PKC isoform which is activated in response to many different kinds of stimuli causing translocation from the cytosol to specialized cellular compartments. Therefore, PKC alpha has been implicated in a variety of cellular functions including proliferation, apoptosis, differentiation, motility, and inflammation which are modulated by dynamic interactions with cell-type specific factors, substrates, modulators and PKC anchoring proteins.
Human PKC alpha, recombinantly expressed in Sf9 cells, C-terminal His-fusion protein. Molecular weight based on amino acid sequence 81.9 kDa. Purity > 95% (SDS PAGE).
Specific activity : 394,200 U*/mg
* 1 Unit is defined as 1 picomole phosphate transferred to PKC substrate peptide (QKRPSQRSKYL) per min at 30 oC
Protein concentration: 0.4 mg/ml (Bradford method using BSA as standard protein)
Size: 10 µg
Ordering information: shipped on dry ice
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