Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: IGF1R
| Gene Symbol: CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216
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Gene Name Synonyms: CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216
| NCBI Acc#: NM_000875
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Chromosomal Location: 15q26.3
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