Background
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
|
Purification Method: FPLC
| |
Gene/Protein Information
Gene Name: IRAK4
| Gene Symbol: NYREN64, REN64
|
Gene Name Synonyms: NYREN64, REN64
| NCBI Acc#: NM_016123
|
Chromosomal Location: 12q12
| |
