Background
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: JAK3
| Gene Symbol: JAK3, JAK3_HUMAN, JAKL, LJAK, LJAK
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Gene Name Synonyms: JAK3, JAK3_HUMAN, JAKL, LJAK, LJAK
| NCBI Acc#: NM_000215
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Chromosomal Location: 19p13.1
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