Background
The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
|
Purification Method: FPLC
| |
Gene/Protein Information
Gene Name: LMTK2
| Gene Symbol: AATYK2, BREK, KIAA1079, KPI2, KPI2, LMR2, cprk
|
Gene Name Synonyms: AATYK2, BREK, KIAA1079, KPI2, KPI2, LMR2, cprk
| NCBI Acc#: NM_014916
|
Chromosomal Location: 7q21.3
| |
