mitogen-activated protein kinase kinase 5, MAP2K5
MAP kinase kinase MEK5b, MAPK/ERK kinase 5, dual specificity mitogen-activated protein kinase kinase 5

  Background  
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq].

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  Gene/Protein Information