Background
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: MAP3K11
| Gene Symbol: MGC17114, MLK3, MLK3, PTK1, SPRK
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Gene Name Synonyms: MGC17114, MLK3, MLK3, PTK1, SPRK
| NCBI Acc#: NM_002419
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Chromosomal Location: 11q13.1-q13.3
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