Background
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: NPR2
| Gene Symbol: AMDM, ANPRB, GUC2B, GUCY2B, NPRB, NPRBi
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Gene Name Synonyms: AMDM, ANPRB, GUC2B, GUCY2B, NPRB, NPRBi
| NCBI Acc#: NM_003995
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Chromosomal Location: 9p21-p12
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