Background
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: OBSCN
| Gene Symbol: DKFZp666E245, FLJ14124, KIAA1556, MGC120409, MGC120410, MGC120411, MGC120412, MGC138590, UNC89
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Gene Name Synonyms: DKFZp666E245, FLJ14124, KIAA1556, MGC120409, MGC120410, MGC120411, MGC120412, MGC138590, UNC89
| NCBI Acc#: NM_052843
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Chromosomal Location: 1q42.13
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