Background
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq].
Product Information
Source: Purified from human 293 cells expressing 358-718 amino acids of Q02156_358-718 (kinase domain: 408-668). Contact us for custom expression of this protein in 293 or Sf9 cells
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: PRKCE
| Gene Symbol: MGC125656, MGC125657, PKCE, nPKCepsilon
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Gene Name Synonyms: MGC125656, MGC125657, PKCE, nPKCepsilon
| NCBI Acc#: Q02156
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Sequence
ELENNIRKAL...LTLVDEAIVK
Storage Condition
Store at 4°C if entire vial will be used within 2 weeks. Store frozen at -20°C or -80°C for longer periods of time.
