Background
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.[supplied by OMIM].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: PRKDC
| Gene Symbol: DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350
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Gene Name Synonyms: DNAPK, DNPK1, HYRC, HYRC1, XRCC7, p350
| NCBI Acc#: NM_006904
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Chromosomal Location: 8q11
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