Background
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: TEK
| Gene Symbol: CD202B, TIE2, TIE2, VMCM, VMCM1
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Gene Name Synonyms: CD202B, TIE2, TIE2, VMCM, VMCM1
| NCBI Acc#: NM_000459
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Chromosomal Location: 9p21
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