Background
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: TGFBR1
| Gene Symbol: AAT5, ACVRLK4, ALK5, ALK5, SKR4, TGFR1
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Gene Name Synonyms: AAT5, ACVRLK4, ALK5, ALK5, SKR4, TGFR1
| NCBI Acc#: NM_004612
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Chromosomal Location: 9q22
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