Background
TRPCs, mammalian homologs of the Drosophila transient receptor potential (trp) protein, are ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM].
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: TRPM7
| Gene Symbol: CHAK, CHAK1, FLJ20117, FLJ25718, LTRPC7, TRPPLIK
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Gene Name Synonyms: CHAK, CHAK1, FLJ20117, FLJ25718, LTRPC7, TRPPLIK
| NCBI Acc#: NM_017672
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Chromosomal Location: 15q21
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