Background
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
Product Information
Source: HEK293
| Purity: >95% by SDS-PAGE analysis
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: WNK4
| Gene Symbol: PHA2B, PRKWNK4
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Gene Name Synonyms: PHA2B, PRKWNK4
| NCBI Acc#: NM_032387
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Chromosomal Location: 17q21-q22
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