Description
Organelles of the secretory and endocytic pathways are distinguished by their luminal acidity, which is generated by the activity of an electrogenic vacuolar-type hydrogen ATPase. Progressive acidification of vesicles in the endocytic pathway is essential for the redistribution and degradation of internalized membrane proteins, such as ligand receptor complexes and fluid-phase solutes. This gene is expressed predominantly in the trans-Golgi network, and mediates the influx of sodium or potassium in exchange for hydrogen. It may thus play an important role in maintaining cation homeostasis and function of the trans-Golgi network. This gene is part of a gene cluster on chromosome Xp11.23. [provided by RefSeq]
Product Information
Source: E coli; insect cells; or mammalian cells: 293, CHO
| Purity: Greater than 95% as determined by RP-HPLC or SDS-PAGE analysis.
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Purification Method: FPLC Chromatography.
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Gene/Protein Information
Gene Name: 1-aminocyclopropane-1-carboxylate synthase homolog
| Gene Symbol: ACCS
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Gene Name Synonyms: ACS; PHACS
| NCBI Acc#: NM_032592
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SwissProt: Q96QU6
| Omim: 608405
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Chromosomal Location: 11p11
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Availability
Custom Expression: 4 to 10 weeks
