Background
Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined. [provided by RefSeq].
Product Information
Source: E coli; insect cells; or mammalian cells: 293, CHO
| Purity: Greater than 95% as determined by RP-HPLC or SDS-PAGE analysis.
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Purification Method: FPLC Chromatography.
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Gene/Protein Information
Gene Name: apobec-1 complementation factor isoform 1
| Gene Symbol: A1CF
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Gene Name Synonyms: ACF; ACF64; ACF65; APOBEC1CF; ASP;
| NCBI Acc#: NM_014576
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SwissProt: Q9NQ94
| Chromosomal Location: 10q21.1
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Availability
Custom Expression: 4 to 10 weeks
