Background
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode different isoforms. Pseudogenes corresponding to this gene are found on chromosomes 5q and 12q. [provided by RefSeq].
Product Information
Source: E coli; insect cells; or mammalian cells: 293, CHO
| Purity: Greater than 95% as determined by RP-HPLC or SDS-PAGE analysis.
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: mitochondrial ribosomal protein L11 isoform b
| Gene Symbol: MRPL11
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Gene Name Synonyms: CGI-113; L11MT; MGC111024; MRP-L11
| NCBI Acc#: NM_170738
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Availability
Custom Expression: 4 to 10 weeks
