Background
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq].
Product Information
Source: E coli; insect cells; or mammalian cells: 293, CHO
| Purity: Greater than 95% as determined by RP-HPLC or SDS-PAGE analysis.
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Purification Method: FPLC
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Gene/Protein Information
Gene Name: NLR family, pyrin domain containing 3 isoform a
| Gene Symbol: NLRP3
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Gene Name Synonyms: AGTAVPRL; AII; AII/AVP; AVP; C1orf7; CIAS1;
| NCBI Acc#: NM_001079821
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Availability
Custom Expression: 4 to 10 weeks
