Background
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.
Product Information
Source: E coli; insect cells; or mammalian cells: 293, CHO
| Purity: Greater than 95% as determined by RP-HPLC or SDS-PAGE analysis.
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Purification Method: FPLC Chromatography.
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Gene/Protein Information
Gene Name: prestin isoform a
| Gene Symbol: SLC26A5
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Gene Name Synonyms: DFNB61; MGC118886; MGC118887; MGC118888;
| NCBI Acc#: NM_198999
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SwissProt: P58743
| Omim: 604943
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Chromosomal Location: 7q22
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Availability
Custom Expression: 4 to 10 weeks
