Background
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq].
Product Information
Source: E coli; insect cells; or mammalian cells: 293, CHO
| Purity: Greater than 95% as determined by RP-HPLC or SDS-PAGE analysis.
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Purification Method: FPLC Chromatography.
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Gene/Protein Information
Gene Name: sex-determining region Y-box 2
| Gene Symbol: SOX2
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Gene Name Synonyms: ANOP3; MCOPS3; MGC2413
| NCBI Acc#: NM_003106
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SwissProt: P48431
| Omim: 184429
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Chromosomal Location: 3q26.3-q27
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Availability
Custom Expression: 4 to 10 weeks
